PUBLICATIONS

2023

eIF3d controls the persistent integrated stress response.

Mukhopadhyay S, Amodeo ME, Lee ASY.
Molecular Cell. 2023. Online Sept 7 [Web]

2022

Moonlighting translation factors: multifunctionality drives diverse gene regulation.

Farache D*, Antine SP*, Lee ASY. (*co-first).
Trends in Cell Biology. 2022. 32(9): 762-772 [Web]

Eukaryotic initiation factor 5A2 regulates expression of antiviral genes.

Farache D, Liu L, Lee ASY.
Journal of Molecular Biology. 2022. 434(10): 167564 [Web]

2021

LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy.

Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee ASY, Dominguez D, Ting DT, Daley GQ.
Journal of Clinical Investigation. 2021. 131(22): e145142. [Web]

cGAS-like receptors sense RNA and control 3′2′-cGAMP signaling in Drosophila.

Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ.
Nature. 2021 Jul 14; 597: 109-113. [Web]

2020

A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress.

Lamper AM*, Fleming RH*, Ladd KM*, Lee ASY. (*co-first)
Science. 2020 Nov 13; 370(6518): 853-856. [Web]

CBASS immunity uses CARF-related effectors to sense 3'–5'- and 2'–5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection.

Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ.
Cell. 2020 July 9; 182, 1-12. [Web]

A molecular filter for the cnidarian stinging response.

Weir K, Dupre C, Giesen van L, Lee ASY, Bellono NW.
eLIFE. elife 2020;9:e57578. [Web]

2019

Repression of ferritin light chain translation by human eIF3.

Pulos-Holmes MC, Srole DN, Juarez MG, Lee ASY, McSwiggen DT, Ingolia NT, Cate JH.
eLIFE. eLife 2019;8:e48193. [Web]

A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents.

Blower TR*, Bandak A*, Lee ASY, Austin CA, Nitiss JL, Berger JM. (*co-first).
Nucleic Acids Research. 2019 Sep 5; 47(15): 8163-8179. [Web]

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kB Signaling Adaptation.

de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY+, Kranzusch PJ+. (+co-corresponding)
Cell Reports. 2019 April 23; 201927, 1–11. [Web]

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.

Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ+, Kranzusch PJ+. (+Co-corresponding)
Nature. 2019 Mar 19; 567(7747):194-199. [Web]

2016 + prior

eIF3d is an mRNA cap-binding protein required for specialized translation initiation.

Lee ASY, Kranzusch PJ, Doudna JA, Cate JH.
Nature. 2016 Aug 4; 10.1038/nature18954. [Web]

Ancient Origin of cGAS-STING reveals mechanism of universal 2’, 3’ cGAMP signaling.

Kranzusch PJ*, Wilson SC*, Lee ASY, Berger JM, Doudna JA, Vance RE. (*Co-first)
Molecular Cell. 2015 Sept 17; 59(6): 891-903. [Web]

eIF3 targets cell proliferation mRNAs for translational activation or repression.

Lee ASY, Kranzusch PJ, Cate JH.
Nature. 2015 Jun 04; 522:111-114. [Web]

Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity.

Nuñez JK, Lee ASY, Engelman A, Doudna JA.
Nature. 2015 Mar 12; 519:193-198. [Web]

Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.

Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.
Cell. 2014 Aug 28; 158(5):1011-1021. [Web]

Host factors required for vesicular stomatitis virus infection.

Lee ASY, Burdeinick-Kerr R, Whelan S.P.
Journal of Virology. 2014 Aug 1; 88(15): 8355-8360. [Web]

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Kranzusch PJ, Lee ASY, Berger JM, Doudna JA.
Cell Reports. 2013 May 23; 3(5): 1362-1368. [Web]

A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs.

Lee ASY, Burdeinick-Kerr R, Whelan S.P.
Proc Natl Acad Sci USA. 2013 Jan 2; 110(1): 324-9. 2007-2012 [Web]

Construction and manipulation of a new Kaposi’s sarcoma-associated herpesvirus bacterial artificial chromosome clone.

Brulois K, Chang H, Lee ASY, Ensser A, Wong LY, Toth Z, Lee SH, Lee HR, Myoung J, Ganem DE, Oh TK, Kim JF, Gao SG, Jung JU.
Journal of Virology. 2012 Sept; 86(18): 9708-9720.

Peroxisomes are signaling platforms for antiviral innate immunity.

Dixit E, Boulant S, Zhang Y, Lee ASY, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC.
Cell. 2010 May 14;141(4):668-81.

Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice.

Ge Z, Lee A, Whary MT, Rogers AB, Maurer KJ, Taylor NS, Schauer DB, Fox JG.
Microbial Pathogenesis. 2008 Jul; 45(1): 18-24.

Receptor Determinants of Zoonotic Transmission of New World Hemorrhagic Fever Arenaviruses.

Radioshitzky S, Kuhn J, Spiropoulous C, Albarino C, Nguyen D, Salazar-Bravo J, Dorfman T, Lee AS, Wang E, Ross S, Choe H, Farzan M.
Proc Natl Acad Sci USA. 2008 Feb 19;105(7):2664-9.

Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis.

Ge Z, Rogers AB, Feng Y, Lee A, Xu S, Taylor NS, Fox JG.
Cell Microbiology. 2007 Aug; 9(8): 2070-2080.