We study how cells sense and respond to their environment by regulating mRNA translation.

Recent News

Mar 28: Our paper revealing a new function for the eIF5A2 protein in regulating an intrinsic antiviral gene expression program is published at JMB! Read it here: Eukaryotic initiation factor 5A2 regulates expression of antiviral genes.

Dec 1: Our research is supported by a Basic Research Grant from the DFCI Innovations Research Fund.

Aug 16: Our lab is funded by a Maximizing Investigators' Research Award (MIRA R35) from NIH NIGMS.

Jul 14: Our collaboration with the Kranzusch lab on cGAS-like receptor sensing of RNA in Drosophila is published at Nature.

Nov 13: Our paper describing a new mechanism of translation reprogramming that is critical for the cellular response to metabolic stress is published at Science! Read it here: "A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress."

Join us!

We are seeking motivated and creative scientists to join our team.

Post-doctoral fellows: Recent Ph.D. graduates with a strong record of publication and training in molecular/cell biology or biochemistry can send a C.V. and contact information for 3 references to amysy_lee [at] dfci.harvard.edu.

Graduate students can join the lab through the BBS and Virology graduate programs at Harvard. Email for information on rotation projects.

Undergraduates: Email with a C.V. and cover letter including research interests.

All content © Amy Lee 2021